It's important to ask a question that can be answered through use of evidence rather than subjective judgment. Evidence-based medicine (EBM) - like evidence-based practice in any discipline - draws on empirical evidence. This may include laboratory studies, clinical trials, and real-world prospective or retrospective studies. You may need to rephrase the question according to whether the evidence base is in diagnosis, therapy & interventions, prognosis, or assessments of harm.
Formulating a strong research question for a systematic review can be a lengthy process. While you may have an idea about the topic you want to explore, your specific research question is what will drive your review and requires some consideration.
You will want to conduct preliminary or exploratory searches of the literature as you refine your question. In these searches you will want to:
A narrow and specific research question is required in order to conduct a systematic review. The goal of a systematic review is to provide an evidence synthesis of ALL research performed on one particular topic. Your research question should be clearly answerable from the studies included in your review.
Another consideration is whether the question has been answered enough to warrant a systematic review. If there have been very few studies, there won't be enough qualitative and/or quantitative data to synthesize. You then have to adjust your question... widen the population, broaden the topic, reconsider your inclusion and exclusion criteria, etc.
When developing your question, it can be helpful to consider the FINER criteria (Feasible, Interesting, Novel, Ethics, and Relevant). Read more about the FINER criteria on the Elsevier blog.
Here are some examples of good systematic review questions and questions that are better suited for different types of reviews:
| Sample Question | Suitable Review Type |
| What is the effectiveness of talk therapy in treating ADHD in children? | Systematic Review |
| What treatments are available for treating children with ADHD? | Systematic Map/Scoping Review |
| Are animal-assisted therapies as effective as traditional cognitive behavioral therapies in treating people with depressive disorders? | Systematic Review |
| In adults with PTSD, how effective is cognitive behavioral therapy (CBT) compared to EMDR in reducing symptoms? | Systematic Review |
| What are the experiences of marginalized populations in accessing mental health care? | Scoping Review |
Frameworks like PICO, SPIDER, and SPICE help you clearly define your research question and guide your search strategy. Each one is designed to fit different types of research—whether you're focusing on clinical interventions, qualitative experiences, or policy and service evaluations.
Using a framework:
Choosing the right framework improves both the quality and credibility of your systematic review.
| PICO | SPIDER | SPICE |
|---|---|---|
|
Primarily used for clinical and intervention-based research questions. |
Developed for qualitative and mixed-methods research, providing a more specific framework than PICO for these approaches. | The SPICE framework is useful for qualitative research topics evaluating the outcomes of a service, project or intervention. |
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Before starting your systematic review, it's essential to check whether your topic has already been reviewed, or is currently being reviewed. Systematic reviews are meant to offer new or updated insights, not duplicate existing work.
By searching protocols and published reviews first, you can:
Avoid duplicating work
Confirm your topic is original or necessary as an update
Find gaps or angles others haven’t covered
Strengthen your proposal or publication potential
A protocol is a detailed plan for a systematic review that outlines:
The research question
Which databases will be searched
The criteria for including or excluding studies
How data will be extracted and analyzed
Researchers register protocols before they start the review to promote transparency and reduce duplication. Think of a protocol like a blueprint for a building—it shows what the final review will look like before any “construction” begins.
To search for protocols (systematic reviews that are in progress):
To search for dissertations (systematic reviews by previous Pepperdine PsyD graduates):
To search for published systematic reviews:
Librarians can help you learn how to search for existing information on your topic. Finding existing reviews on your topic will inform the development of your research question, identify gaps, and confirm that you are not duplicating the efforts of previous reviews (duplicated research / research waste).
Cantrell, Sarah. LibGuides: Systematic Reviews: 2. Develop a Research Question. https://guides.mclibrary.duke.edu/sysreview/question. Accessed 7 Aug. 2025.
Condron, Patrick. Library Guides: Systematic Reviews for STEMM: The Research Question. https://unimelb.libguides.com/sysrev/research-question. Accessed 7 Aug. 2025.
Jones, Emily. LibGuides: Systematic Reviews: Step 1: Complete Pre-Review Tasks. https://guides.lib.unc.edu/systematic-reviews/pre-review. Accessed 7 Aug. 2025.
Kibbee, Matthew. LibGuides: A Guide to Evidence Synthesis: 1. Draft Your Research Question. https://guides.library.cornell.edu/evidence-synthesis/research-question. Accessed 7 Aug. 2025.
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